Telomeres and telomerase in endometrial cancer and hyperplasia-Reference-Cited by-同舟云学术

Telomeres and telomerase in endometrial cancer and hyperplasia

Published:2024-03-30 Issue:2 Volume:20 Page:682-685
ISSN:1734-1922
Container-title:Archives of Medical Science
language:
Short-container-title:Arch Med Sci

Author:

Pańczyszyn Anna¹^ORCID,Boniewska-Bernacka Ewa¹,Włodarczyk Karolina²,Wertel Iwona²,Goc Anna¹

Affiliation:

1. Institute of Medical Sciences, Department of Biology and Genetics, Faculty of Medicine, University of Opole, Opole, Poland

2. Independent Laboratory of Cancer Diagnostics and Immunology, Medical University of Lublin, Lublin, Poland

Abstract

IntroductionThe study aimed to measure telomeres length (TL) and telomerase expression in normal endometrium and endometrial hyperplasia and cancer.Material and methodsTotal RNA and DNA were isolated from endometrium samples of 117 patients. The RT-PCR method was used to determine telomerase expression and relative telomere length.ResultsThe control group had the longest telomeres in comparison to the hyperplasia and endometrial cancer groups. Only in the endometrial cancer group was telomerase expressed and positively correlated with telomere length.ConclusionsTelomere extension in endometrial cancer is mediated by telomerase, but telomere length may not be an indicator of endometrioid cancer development.

Publisher

Termedia Sp. z.o.o.

Link

https://www.archivesofmedicalscience.com/pdf-186189-109425

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