1. Department of Pharmacology and Toxicology, PO Box 5000, FIN-90014, University of Oulu, Finland.
2. Novamass Ltd, Medipolis Center, Kiviharjuntie 11, FIN-90220, Oulu, Finland
3. Institute of Clinical Pharmacology, Stuttgart, Germany and Department of Clinical Pharmacology, University of Tübingen, Auerbachstrasse 112, DE-70376 Stuttgart, Germany
4. Department of Pharmacology and Toxicology, PO Box 1627, FIN-70211 University of Kuopio, Finland