Metabolism: A Bottleneck in In Vitro Toxicological Test Development

Author:

Coecke Sandra1,Ahr Hans2,Blaauboer Bas J.3,Bremer Susanne1,Casati Silvia1,Castell Josè4,Combes Robert5,Corvi Raffaella1,Crespi Charles L.6,Cunningham Michael L.7,Elaut Greetje8,Eletti Brighitta1,Freidig Andreas9,Gennari Alessandra1,Ghersi-Egea Jean-François10,Guillouzo Andre11,Hartung Thomas1,Hoet Peter12,Ingelman-Sundberg Magnus13,Munn Sharon14,Janssens Walter15,Ladstetter Bernhard16,Leahy David17,Long Anthony18,Meneguz Annarita19,Monshouwer Mario20,Morath Siegfried21,Nagelkerke Fred22,Pelkonen Olavi23,Ponti Jessica1,Prieto Pilar1,Richert Lysianne24,Sabbioni Enrico1,Schaack Beatrice25,Steiling Winfried26,Testai Emanuela27,Vericat Joan-Albert28,Worth Andrew14

Affiliation:

1. ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy

2. Bayer AG, PH-PD Toxicology, Wuppertal, Germany

3. Institute for Risk Assessment Sciences, Division of Toxicology, Unit of Biochemical Toxicology, Utrecht University, Utrecht, The Netherlands

4. Hospital Universitari La Fe, Valencia, Spain

5. FRAME, Nottingham, UK

6. Gentest, BD Biosciences, Woburn, MA, USA

7. National Center for Toxicogenomics & National Toxicology Program, National Institutes of Health, National Institute of Environmental Health Sciences, NC, USA

8. Vrije Universiteit Brussel, Department of Toxicology, Brussels, Belgium

9. TNO Nutrition and Food Research, Department of Biomolecular Sciences, Zeist, The Netherlands

10. INSERM U433, Faculté de Médecine Laënnec, Lyon, France

11. INSERM U456, Rennes Cedex, France

12. KU. Leuven, Laboratorium voor Pneumologie (Lung Toxicologie), Leuven, Belgium

13. Karolinska Institute, Molecular Toxicology, Stockholm, Sweden

14. ECB, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy

15. Scientific Institute for Public Health, Division of Toxicology, Brussels, Belgium

16. Merck KGaA, Institute of Drug Metabolism and Pharmacokinetics, Grafing, Germany

17. Cyprotex PLC, Macclesfield, Cheshire, UK

18. LHASA Limited, Department of Chemistry, University of Leeds, Leeds, UK

19. Department of Drug Research and Evaluation, Biochemical Pharmacology and Technical Scientific Advice Coordination Unit, Rome, Italy

20. Investigative ADME, Pharmacokinetics, Dynamics & Metabolism, Pharmacia, Gruppo Pfizer Inc., Nerviano, Italy

21. University of Konstanz, Biochemical Pharmacology, Konstanz, Germany

22. LACDR, Leiden University, Gorlaeus Laboratories, Leiden, The Netherlands

23. Department of Pharmacology and Toxicology, University of Oulu, Finland

24. University of Besancon, UFR Medicine, Pharmacie, Besacon, France

25. CEA Grenoble-DRDC, Lboratoire BioPuces, Grenoble Cedex, France

26. Product Safety, Toxicology, Dusseldorf, Germany

27. Istituto Superiore di Sanita, Department of Environment and Primary Prevention-Mechanisms of Toxicity Unit, Rome, Italy

28. NeuroPharma, Cantos (Madrid), Spain

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference202 articles.

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