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Keeping carbon dioxide in check

Published:2017-05-17 Issue: Volume:6 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Garcia Alfredo J¹^ORCID,Ramirez Jan-Marino²³^ORCID

Affiliation:

1. Institute for Integrative Physiology and the Section of Emergency Medicine, University of Chicago, Chicago, United States

2. Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, United States

3. Department of Neurological Surgery, University of Washington School of Medicine, Seattle, United States

Abstract

The response of the brainstem to increased levels of carbon dioxide in the blood is coordinated with the response of the cardiovascular system.

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://cdn.elifesciences.org/articles/27563/elife-27563-v1.pdf

Reference5 articles.

1. Astrocytes control breathing through pH-dependent release of ATP;Gourine;Science,2010

2. Central respiratory chemoreception;Guyenet; Journal of Comparative Neurology,2010

3. Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe;Hawkins;eLife,2017

4. Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons;Kumar;Science,2015

5. Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem;Ward;Current Opinion in Pharmacology,2009

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