Regulation of breathing by CO 2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons-Reference-Cited by-同舟云学术

Regulation of breathing by CO 2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons

Published:2015-06-12 Issue:6240 Volume:348 Page:1255-1260
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kumar Natasha N.¹,Velic Ana²,Soliz Jorge³⁴,Shi Yingtang¹,Li Keyong¹,Wang Sheng¹⁵,Weaver Janelle L.¹,Sen Josh¹,Abbott Stephen B. G.¹⁶⁷,Lazarenko Roman M.¹,Ludwig Marie-Gabrielle⁸,Perez-Reyes Edward¹,Mohebbi Nilufar²,Bettoni Carla²,Gassmann Max³,Suply Thomas⁸,Seuwen Klaus⁸,Guyenet Patrice G.¹,Wagner Carsten A.²,Bayliss Douglas A.¹

Affiliation:

1. Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA.

2. Institute of Physiology, University of Zurich, Zurich, CH-8057, Switzerland.

3. Institute of Veterinary Physiology, University of Zurich, Zurich, CH-8057, Switzerland.

4. Centre de Recherche du CHU de Québec, Département de Pédiatrie, Faculté de Médecine, Université Laval, Québec, QC, Canada.

5. Department of Physiology, Hebei Medical University, Shijiazhuang, Hebei, 050017, China.

6. School of Medical Sciences, University of New South Wales, New South Wales 2052, Australia.

7. Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.

8. Novartis Institutes for Biomedical Research, Basel, CH-4002, Switzerland.

Abstract

Receptor in the brain controls breathing Control of breathing in mammals depends primarily not on sensing oxygen, but rather on detecting concentrations of carbon dioxide in the blood. Failure of this system can cause potentially deadly sleep apnias. Taking a hint from insects, which use a heterotrimeric guanine nucleotide–binding protein-coupled receptor (GPCR) to sense carbon dioxide, Kumar et al. demonstrate that the GPCR GPR4 is essential to control breathing in mice. GPR4 senses protons generated by the formation of carbonic acid in the blood and works with a pH-sensitive potassium channel called TASK-2 in a set of brain cells that control breathing. Science , this issue p. 1255

Funder

National Institutes of Health

Swiss National Science Foundation

National Health and Medical Research Council of Australia Early Career Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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