Phytosomes and Recent research on Phytosomal Drugs

Abstract

Novel drug delivery system aims to improve limitations of conventional drug delivery systems. A novel drug delivery approach helps to increase the bioavailability and stability of herbal drugs and phytoconstituients. Phytosomes the term "phyto" refers to the plant, while "some" refers to cell‐like. Phytosomes are prepared by treating standardized plant extracts into phospholipids mainly phosphatidylcholine to produce compatible phyto-phospholipid complexes. Phytosome technology mainly enhances the bioavailability, gastrointestinal solubility, and lipid solubility of the compound. For example, Vasicine is a potential bronchodilator and is used for the treatment of asthma and bronchitis. Due to poor solubility, absorption in GIT decreases which leads to low bioavailability of vaccine. By using the phytosome technology solubility and absorption are enhanced which leads to improved bioavailability of vasicine. The objective of this review is that how vasaka extract, quercetin, and other drugs show to improve its bioavailability by enhancing the solubility and absorption by using phytosomal preparation and to know about recent research and applications of phytosomes.