Pharmacosome as a Vesicular Drug Delivery System

Abstract

In the area of solubility enhancement, several problems are encountered. Pharmacosomes are a new technology based on lipid drug carriers. Pharmacosomes are colloidal, vesicles, nanometric size micelles or a hexagonal arrangement of colloidal drug dispersions covalently attached to the phospholipid. Because of their unique properties such as active drug loading, small size, high entrapment efficiency, amphiphilicity and stability, they act as a precise drug carrier. They contribute to the controlled release of medicament at the action site, as well as the reduction of therapy cost, increased bioavailability of poorly soluble drugs, decrease toxicity and drug leakage. There has been an advancement in the scope of this delivery system for a number of drugs used for cancer, heart diseases, inflammation and protein delivery besides with a large number of herbal drugs. Pharmacosomes offer new opportunities and challenges for developing a more effective new vesicular drug delivery system.