Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency
Author:
Publisher
American Society for Clinical Investigation
Link
https://www.jci.org/articles/view/175199/files/pdf
Reference24 articles.
1. Acute lymphoblastic leukemia: a comprehensive review and 2017 update
2. Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19
3. Mechanisms underlying CD19-positive ALL relapse after anti-CD19 CAR T cell therapy and associated strategies
4. Anti-CD19 resistance can “stem” from progenitors
5. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T cells in pediatric acute lymphoblastic leukemia
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