Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Cancer Research,Hematology
Link
http://www.nature.com/articles/s41375-019-0580-z.pdf
Reference20 articles.
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2. Shah NN, Fry TJ. Anti-CD19 resistance can “stem” from progenitors. Blood. 2017;130:1961–3.
3. Bagashev A, Sotillo E, Tang C-HA, Black KL, Perazzelli J, Seeholzer SH, et al. CD19 alterations emerging after CD19-directed immunotherapy cause retention of the misfolded protein in the endoplasmic reticulum. Mol Cell Biol. 2018;38:e00383–18.
4. Braig F, Brandt A, Goebeler M, Tony HP, Kurze AK, Nollau P, et al. Resistance to anti-CD19/CD3 BiTE in acute lymphoblastic leukemia may be mediated by disrupted CD19 membrane trafficking. Blood. 2017;129(5):100–4.
5. Zheng S, Asnani M, Thomas-Tikhonenko A. Escape from ALL-CARTaz: leukemia immunoediting in the age of chimeric antigen receptors. Cancer J. 2019; 25.
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