Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19-Reference-Cited by-同舟云学术

Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19

Published:2019-10-07 Issue:4 Volume:34 Page:1202-1207
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Asnani Mukta,Hayer Katharina E.^ORCID,Naqvi Ammar S.,Zheng Sisi,Yang Scarlett Y.^ORCID,Oldridge Derek,Ibrahim Fadia,Maragkakis Manolis^ORCID,Gazzara Matthew R.,Black Kathryn L.,Bagashev Asen,Taylor Deanne^ORCID,Mourelatos Zissimos,Grupp Stephan A.,Barrett David,Maris John M.,Sotillo Elena,Barash Yoseph,Thomas-Tikhonenko Andrei^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/s41375-019-0580-z.pdf

Reference20 articles.

1. June CH, Sadelain M. Chimeric antigen receptor therapy. N Engl J Med. 2018;379:64–73.

2. Shah NN, Fry TJ. Anti-CD19 resistance can “stem” from progenitors. Blood. 2017;130:1961–3.

3. Bagashev A, Sotillo E, Tang C-HA, Black KL, Perazzelli J, Seeholzer SH, et al. CD19 alterations emerging after CD19-directed immunotherapy cause retention of the misfolded protein in the endoplasmic reticulum. Mol Cell Biol. 2018;38:e00383–18.

4. Braig F, Brandt A, Goebeler M, Tony HP, Kurze AK, Nollau P, et al. Resistance to anti-CD19/CD3 BiTE in acute lymphoblastic leukemia may be mediated by disrupted CD19 membrane trafficking. Blood. 2017;129(5):100–4.

5. Zheng S, Asnani M, Thomas-Tikhonenko A. Escape from ALL-CARTaz: leukemia immunoediting in the age of chimeric antigen receptors. Cancer J. 2019; 25.

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