Anti-CD19 resistance can “stem” from progenitors
Author:
Affiliation:
1. NATIONAL CANCER INSTITUTE
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/130/18/1961/1403193/blood804070.pdf
Reference10 articles.
1. Hematopoietic stem cell involvement in BCR-ABL1–positive ALL as a potential mechanism of resistance to blinatumomab therapy;Nagel;Blood,2017
2. Convergence of acquired mutations and alternative splicing of CD19 enables resistance to CART-19 immunotherapy;Sotillo;Cancer Discov,2015
3. CD19 isoforms enabling resistance to CART-19 immunotherapy are expressed in B-ALL patients at initial diagnosis;Fischer;J Immunother,2017
4. CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity;Jacoby;Nat Commun,2016
5. Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy;Gardner;Blood,2016
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1. Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency;Journal of Clinical Investigation;2024-02-20
2. Chimeric Antigen Receptor T-cell Therapy;Hematology/Oncology Clinics of North America;2022-08
3. CAR T cell therapy: newer approaches to counter resistance and cost;Heliyon;2020-04
4. CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy;Blood Advances;2019-11-18
5. Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19;Leukemia;2019-10-07
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