Affiliation:
1. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Abstract
Abstract
In intensity-modulated proton therapy, robust optimization processes have been developed to manage uncertainties associated with (1) range, (2) setup, (3) anatomic changes, (4) dose calculation, and (5) biological effects. Here we review our experience using a robust optimization technique that directly incorporates range and setup uncertainties into the optimization process to manage those sources of uncertainty. We also review procedures for implementing adaptive planning to manage the anatomic uncertainties. Finally, we share some early experiences regarding the impact of uncertainties in dose calculation and biological effects, along with techniques to manage and potentially reduce these uncertainties.
Publisher
International Journal of Particle Therapy
Subject
Radiology, Nuclear Medicine and imaging,Atomic and Molecular Physics, and Optics
Cited by
3 articles.
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