MEASURING CARDIAC OUTPUT THROUGH THERMODILUTION BASED ON MACHINE LEARNING

Abstract

Cardiac output (CO) refers to the amount of blood ejected from a unilateral ventricle per minute and is an important measure of cardiac function. Thermodilution is the gold standard for CO measurement because of its accuracy. However, the traditional thermodilution method requires calibration of the correction factor before measurement, which makes its practical application difficult. Therefore, conducting CO measurement by using a machine-learning-based thermodilution method is proposed in this paper, and CO is regressed and predicted through the thermodilution curve by a machine learning model. In this paper, we constructed five cardiac vascular models, and three of them were randomly selected to simulate the thermodilution process. Nine features of the thermodilution curve from the time–frequency domains were extracted and fed into the multilayer perceptron model for training. On the basis of a cross-validation method, the accuracy of the final prediction model was 97.99% ([Formula: see text]%). Simultaneously, a trained neural network was used to predict the CO of the remaining two cardiac vascular models, and the resulting error was within 5%. In this paper, an experimental system consisting of a water pump, a three-way valve and a temperature sensor is also designed, and the thermodilution curves at different quantities of flow are tested and regressed and predicted with the above model, with the error being within 10%, which met the requirement for real-world use, and thus, a method was established for measuring CO by using machine-learning-based thermodilution.