Author:
Hiraki-Kajiyama Towako,Yamashita Junpei,Yokoyama Keiko,Hosono Kohei,Kawabata-Sakata Yukika,Kikuchi Yukiko,Miyazoe Daichi,Ansai Satoshi,Kinoshita Masato,Nagahama Yoshitaka,Okubo Kataaki
Abstract
AbstractMale and female animals display innate sex-specific mating behaviors. Among vertebrates, teleosts are unique in that altering the adult sex steroid milieu can reverse sex-typical mating behaviors, suggesting sexual lability of their brains. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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