Modified Oxacillin Resistant Staphylococcus aureus detected in neonatal intensive care patients-Reference-Cited by-同舟云学术

Modified Oxacillin Resistant Staphylococcus aureus detected in neonatal intensive care patients

Published:2021-03-09 Issue: Volume: Page:
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Author:

Gitman Melissa R.^ORCID,Alburquerque Bremy,van de Guchte Adriana,Sullivan Mitchell J.,Obla Ajay,Polanco Jose,Chung Marilyn,Oussenko Irina,Smith Melissa L.,Samaroo Flora,Barackman Debbie,Altman Deena R.,Sordillo Emilia Mia^ORCID,van Bakel Harm^ORCID

Abstract

AbstractActive surveillance in our neonatal intensive care unit identified Staphylococcus aureus cultures from two infants with heterogeneity in methicillin resistance between isolated subclones lacking mecA and mecC. Whole-genome analysis of 4 modified (MODSA) and 4 methicillin-susceptible (MSSA) subclones for each culture identified either truncating mutations in the cyclic diadenosine monophosphate phosphodiesterase enzyme (GdpP), or a nonsynonymous substitution in penicillin binding protein 2 (PBP2). These cases highlight the difficulty in identifying non-mecA/non-mecC-mediated methicillin-resistance in clinical laboratories.

Publisher

Cold Spring Harbor Laboratory

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