Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes-Reference-Cited by-同舟云学术

Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes

Published:2018-07 Issue:7 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Argudín M. Angeles¹^ORCID,Roisin S.¹,Nienhaus L.¹,Dodémont M.¹,de Mendonça R.¹,Nonhoff C.¹,Deplano A.¹,Denis O.¹²

Affiliation:

1. National Reference Centre for Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium

2. Ecole de Santé Publique, Université Libre de Bruxelles, Brussels, Belgium

Abstract

ABSTRACT Methicillin-resistant Staphylococcus aureus isolates lacking mec genes ( n = 32), collected from Belgian hospitals, were characterized for their β-lactamase production and the presence of mutations in pbp genes, the pbp4 promoter, and genes involved in penicillin-binding protein 4 overproduction ( gdpP and yjbH ). Twelve isolates were β-lactamase hyperproducers (BHPs), while 12 non-BHP isolates might produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations in pbp genes. A few isolates also showed mutations in the pbp4 promoter.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00091-18

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