Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations-Reference-Cited by-同舟云学术

Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations

Published:2022-01-05 Issue: Volume: Page:
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Author:

Chandrasekaran Srinivas Niranj^ORCID,Cimini Beth A.^ORCID,Goodale Amy,Miller Lisa,Kost-Alimova Maria,Jamali Nasim^ORCID,Doench John^ORCID,Fritchman Briana,Skepner Adam,Melanson Michelle,Arevalo John^ORCID,Caicedo Juan C.^ORCID,Kuhn Daniel^ORCID,Hernandez Desiree,Berstler Jim,Shafqat-Abbasi Hamdah^ORCID,Root David,Swalley Sussane,Singh Shantanu^ORCID,Carpenter Anne E.^ORCID

Abstract

AbstractWe present a new, carefully designed and well-annotated dataset of images and image-based profiles of cells that have been treated with chemical compounds and genetic perturbations. Each gene that is perturbed is a known target of at least two compounds in the dataset. The dataset can thus serve as a benchmark to evaluate methods for predicting similarities between compounds and between genes and compounds, measuring the effect size of a perturbation, and more generally, learning effective representations for measuring cellular state from microscopy images. Advancements in these applications can accelerate the development of new medicines.

Publisher

Cold Spring Harbor Laboratory

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