Post-GWAS multiomic functional investigation of theTNIP1locus in Alzheimer’s disease implicates mediation throughGPX3

Abstract

AbstractThe recently reportedTNIP1/GPX3locus from AD GWAS studies was investigated. Using proteomics and other functional omics data, we identified evidence for a functional mechanism linking variants in this locus to decreased CSF GPX3 levels as AD progresses, suggesting a new potential target for intervention.