New insights into the genetic etiology of Alzheimer’s disease and related dementias-Reference-Cited by-同舟云学术

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Published:2022-04 Issue:4 Volume:54 Page:412-436
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Bellenguez Céline^ORCID,Küçükali Fahri^ORCID,Jansen Iris E.,Kleineidam Luca,Moreno-Grau Sonia,Amin Najaf^ORCID,Naj Adam C.,Campos-Martin Rafael,Grenier-Boley Benjamin,Andrade Victor,Holmans Peter A.^ORCID,Boland Anne,Damotte Vincent,van der Lee Sven J.^ORCID,Costa Marcos R.^ORCID,Kuulasmaa Teemu^ORCID,Yang Qiong^ORCID,de Rojas Itziar^ORCID,Bis Joshua C.^ORCID,Yaqub Amber^ORCID,Prokic Ivana^ORCID,Chapuis Julien^ORCID,Ahmad Shahzad^ORCID,Giedraitis Vilmantas^ORCID,Aarsland Dag,Garcia-Gonzalez Pablo^ORCID,Abdelnour Carla,Alarcón-Martín Emilio,Alcolea Daniel^ORCID,Alegret Montserrat,Alvarez Ignacio^ORCID,Álvarez Victoria,Armstrong Nicola J.,Tsolaki Anthoula^ORCID,Antúnez Carmen,Appollonio Ildebrando,Arcaro Marina,Archetti Silvana,Pastor Alfonso Arias,Arosio Beatrice,Athanasiu Lavinia,Bailly Henri,Banaj Nerisa,Baquero Miquel^ORCID,Barral Sandra,Beiser Alexa,Pastor Ana Belén^ORCID,Below Jennifer E.,Benchek Penelope,Benussi Luisa,Berr Claudine^ORCID,Besse Céline,Bessi Valentina^ORCID,Binetti Giuliano,Bizarro Alessandra,Blesa Rafael,Boada Mercè^ORCID,Boerwinkle Eric,Borroni Barbara,Boschi Silvia,Bossù Paola^ORCID,Bråthen Geir^ORCID,Bressler Jan^ORCID,Bresner Catherine^ORCID,Brodaty Henry^ORCID,Brookes Keeley J.^ORCID,Brusco Luis Ignacio,Buiza-Rueda Dolores,Bûrger Katharina,Burholt Vanessa^ORCID,Bush William S.^ORCID,Calero Miguel^ORCID,Cantwell Laura B.,Chene Geneviève,Chung Jaeyoon^ORCID,Cuccaro Michael L.,Carracedo Ángel,Cecchetti Roberta,Cervera-Carles Laura^ORCID,Charbonnier Camille,Chen Hung-Hsin,Chillotti Caterina,Ciccone Simona,Claassen Jurgen A. H. R.,Clark Christopher,Conti Elisa,Corma-Gómez Anaïs,Costantini Emanuele^ORCID,Custodero Carlo,Daian Delphine,Dalmasso Maria Carolina^ORCID,Daniele Antonio,Dardiotis Efthimios,Dartigues Jean-François,de Deyn Peter Paul,de Paiva Lopes Katia^ORCID,de Witte Lot D.^ORCID,Debette Stéphanie^ORCID,Deckert Jürgen,del Ser Teodoro^ORCID,Denning Nicola,DeStefano Anita,Dichgans Martin^ORCID,Diehl-Schmid Janine^ORCID,Diez-Fairen Mónica^ORCID,Rossi Paolo Dionigi,Djurovic Srdjan^ORCID,Duron Emmanuelle,Düzel Emrah,Dufouil Carole^ORCID,Eiriksdottir Gudny,Engelborghs Sebastiaan,Escott-Price Valentina^ORCID,Espinosa Ana,Ewers Michael^ORCID,Faber Kelley M.,Fabrizio Tagliavini^ORCID,Nielsen Sune Fallgaard,Fardo David W.,Farotti Lucia,Fenoglio Chiara,Fernández-Fuertes Marta,Ferrari Raffaele,Ferreira Catarina B.,Ferri Evelyn,Fin Bertrand,Fischer Peter,Fladby Tormod^ORCID,Fließbach Klaus,Fongang Bernard,Fornage Myriam^ORCID,Fortea Juan,Foroud Tatiana M.,Fostinelli Silvia,Fox Nick C.^ORCID,Franco-Macías Emlio,Bullido María J.^ORCID,Frank-García Ana,Froelich Lutz^ORCID,Fulton-Howard Brian,Galimberti Daniela^ORCID,García-Alberca Jose Maria^ORCID,García-González Pablo,Garcia-Madrona Sebastian,Garcia-Ribas Guillermo,Ghidoni Roberta,Giegling Ina,Giorgio Giaccone,Goate Alison M.^ORCID,Goldhardt Oliver,Gomez-Fonseca Duber,González-Pérez Antonio^ORCID,Graff Caroline,Grande Giulia,Green Emma^ORCID,Grimmer Timo,Grünblatt Edna^ORCID,Grunin Michelle,Gudnason Vilmundur^ORCID,Guetta-Baranes Tamar,Haapasalo Annakaisa^ORCID,Hadjigeorgiou Georgios,Haines Jonathan L.,Hamilton-Nelson Kara L.,Hampel Harald,Hanon Olivier,Hardy John,Hartmann Annette M.,Hausner Lucrezia,Harwood Janet^ORCID,Heilmann-Heimbach Stefanie^ORCID,Helisalmi Seppo,Heneka Michael T.,Hernández Isabel,Herrmann Martin J.^ORCID,Hoffmann Per,Holmes Clive,Holstege Henne^ORCID,Vilas Raquel Huerto,Hulsman Marc,Humphrey Jack,Biessels Geert Jan^ORCID,Jian Xueqiu^ORCID,Johansson Charlotte^ORCID,Jun Gyungah R.^ORCID,Kastumata Yuriko^ORCID,Kauwe John,Kehoe Patrick G.^ORCID,Kilander Lena,Ståhlbom Anne Kinhult,Kivipelto Miia,Koivisto Anne,Kornhuber Johannes^ORCID,Kosmidis Mary H.^ORCID,Kukull Walter A.,Kuksa Pavel P.,Kunkle Brian W.,Kuzma Amanda B.,Lage Carmen^ORCID,Laukka Erika J.,Launer Lenore^ORCID,Lauria Alessandra,Lee Chien-Yueh^ORCID,Lehtisalo Jenni,Lerch Ondrej,Lleó Alberto^ORCID,Longstreth William,Lopez Oscar^ORCID,de Munain Adolfo Lopez^ORCID,Love Seth,Löwemark Malin,Luckcuck Lauren,Lunetta Kathryn L.^ORCID,Ma Yiyi^ORCID,Macías Juan,MacLeod Catherine A.^ORCID,Maier Wolfgang,Mangialasche Francesca,Spallazzi Marco,Marquié Marta^ORCID,Marshall Rachel,Martin Eden R.,Montes Angel Martín^ORCID,Rodríguez Carmen Martínez,Masullo Carlo,Mayeux Richard,Mead Simon^ORCID,Mecocci Patrizia,Medina Miguel^ORCID,Meggy Alun,Mehrabian Shima,Mendoza Silvia,Menéndez-González Manuel^ORCID,Mir Pablo,Moebus Susanne,Mol Merel^ORCID,Molina-Porcel Laura,Montrreal Laura,Morelli Laura,Moreno Fermin,Morgan Kevin^ORCID,Mosley Thomas,Nöthen Markus M.^ORCID,Muchnik Carolina^ORCID,Mukherjee Shubhabrata,Nacmias Benedetta^ORCID,Ngandu Tiia,Nicolas Gael^ORCID,Nordestgaard Børge G.^ORCID,Olaso Robert,Orellana Adelina,Orsini Michela,Ortega Gemma,Padovani Alessandro,Paolo Caffarra,Papenberg Goran,Parnetti Lucilla,Pasquier Florence^ORCID,Pastor Pau^ORCID,Peloso Gina^ORCID,Pérez-Cordón Alba^ORCID,Pérez-Tur Jordi^ORCID,Pericard Pierre^ORCID,Peters Oliver,Pijnenburg Yolande A. L.,Pineda Juan A.^ORCID,Piñol-Ripoll Gerard,Pisanu Claudia^ORCID,Polak Thomas,Popp Julius,Posthuma Danielle^ORCID,Priller Josef,Puerta Raquel^ORCID,Quenez Olivier^ORCID,Quintela Inés,Thomassen Jesper Qvist^ORCID,Rábano Alberto,Rainero Innocenzo,Rajabli Farid,Ramakers Inez,Real Luis M.^ORCID,Reinders Marcel J. T.^ORCID,Reitz Christiane^ORCID,Reyes-Dumeyer Dolly,Ridge Perry,Riedel-Heller Steffi^ORCID,Riederer Peter,Roberto Natalia,Rodriguez-Rodriguez Eloy^ORCID,Rongve Arvid^ORCID,Allende Irene Rosas,Rosende-Roca Maitée,Royo Jose Luis,Rubino Elisa,Rujescu Dan,Sáez María Eugenia^ORCID,Sakka Paraskevi,Saltvedt Ingvild^ORCID,Sanabria Ángela,Sánchez-Arjona María Bernal,Sanchez-Garcia Florentino,Juan Pascual Sánchez^ORCID,Sánchez-Valle Raquel,Sando Sigrid B.,Sarnowski Chloé^ORCID,Satizabal Claudia L.^ORCID,Scamosci Michela,Scarmeas Nikolaos,Scarpini Elio,Scheltens Philip,Scherbaum Norbert,Scherer Martin,Schmid Matthias,Schneider Anja,Schott Jonathan M.^ORCID,Selbæk Geir^ORCID,Seripa Davide,Serrano Manuel,Sha Jin,Shadrin Alexey A.^ORCID,Skrobot Olivia,Slifer Susan,Snijders Gijsje J. L.,Soininen Hilkka^ORCID,Solfrizzi Vincenzo^ORCID,Solomon Alina,Song Yeunjoo^ORCID,Sorbi Sandro,Sotolongo-Grau Oscar^ORCID,Spalletta Gianfranco^ORCID,Spottke Annika,Squassina Alessio^ORCID,Stordal Eystein^ORCID,Tartan Juan Pablo,Tárraga Lluís,Tesí Niccolo,Thalamuthu Anbupalam,Thomas Tegos,Tosto Giuseppe^ORCID,Traykov Latchezar,Tremolizzo Lucio,Tybjærg-Hansen Anne,Uitterlinden Andre^ORCID,Ullgren Abbe,Ulstein Ingun,Valero Sergi,Valladares Otto^ORCID,Broeckhoven Christine Van^ORCID,Vance Jeffery,Vardarajan Badri N.,van der Lugt Aad,Dongen Jasper Van,van Rooij Jeroen,van Swieten John,Vandenberghe Rik,Verhey Frans,Vidal Jean-Sébastien^ORCID,Vogelgsang Jonathan^ORCID,Vyhnalek Martin,Wagner Michael^ORCID,Wallon David^ORCID,Wang Li-San,Wang Ruiqi,Weinhold Leonie,Wiltfang Jens^ORCID,Windle Gill,Woods Bob^ORCID,Yannakoulia Mary^ORCID,Zare Habil^ORCID,Zhao Yi,Zhang Xiaoling^ORCID,Zhu Congcong,Zulaica Miren,Laczo Jan,Matoska Vaclav,Serpente Maria,Assogna Francesca,Piras Fabrizio,Piras Federica,Ciullo Valentina,Shofany Jacob,Ferrarese Carlo,Andreoni Simona,Sala Gessica,Zoia Chiara Paola,Zompo Maria Del,Benussi Alberto,Bastiani Patrizia,Takalo Mari,Natunen Teemu,Laatikainen Tiina,Tuomilehto Jaakko,Antikainen Riitta,Strandberg Timo,Lindström Jaana,Peltonen Markku,Abraham Richard,Al-Chalabi Ammar,Bass Nicholas J.,Brayne Carol,Brown Kristelle S.,Collinge John,Craig David,Deloukas Pangiotis,Fox Nick,Gerrish Amy,Gill Michael,Gwilliam Rhian,Harold Denise,Hollingworth Paul,Johnston Jarret A.,Jones Lesley,Lawlor Brian,Livingston Gill,Lovestone Simon,Lupton Michelle,Lynch Aoibhinn,Mann David,McGuinness Bernadette,McQuillin Andrew,O’Donovan Michael C.,Owen Michael J.,Passmore Peter,Powell John F.,Proitsi Petra,Rossor Martin,Shaw Christopher E.,Smith A. David,Gurling Hugh,Todd Stephen,Mummery Catherine,Ryan Nathalie,Lacidogna Giordano,Adarmes-Gómez Ad,Mauleón Ana,Pancho Ana,Gailhajenet Anna,Lafuente Asunción,Macias-García D.,Martín Elvira,Pelejà Esther,Carrillo F.,Merlín Isabel Sastre,Garrote-Espina L.,Vargas Liliana,Carrion-Claro M.,Marín M.,Labrador Ma,Buendia Mar,Alonso María Dolores,Guitart Marina,Moreno Mariona,Ibarria Marta,Periñán Mt,Aguilera Nuria,Gómez-Garre P.,Cañabate Pilar,Escuela R.,Pineda-Sánchez R.,Vigo-Ortega R.,Jesús S.,Preckler Silvia,Rodrigo-Herrero Silvia,Diego Susana,Vacca Alessandro,Roveta Fausto,Salvadori Nicola,Chipi Elena,Boecker Henning,Laske Christoph,Perneczky Robert,Anastasiou Costas,Janowitz Daniel,Malik Rainer,Anastasiou Anna,Parveen Kayenat,Lage Carmen,López-García Sara,Antonell Anna,Mihova Kalina Yonkova,Belezhanska Diyana,Weber Heike,Kochen Silvia,Solis Patricia,Medel Nancy,Lisso Julieta,Sevillano Zulma,Politis Daniel G.,Cores Valeria,Cuesta Carolina,Ortiz Cecilia,Bacha Juan Ignacio,Rios Mario,Saenz Aldo,Abalos Mariana Sanchez,Kohler Eduardo,Palacio Dana Lis,Etchepareborda Ignacio,Kohler Matias,Novack Gisela,Prestia Federico Ariel,Galeano Pablo,Castaño Eduardo M.,Germani Sandra,Toso Carlos Reyes,Rojo Matias,Ingino Carlos,Mangone Carlos,Rubinsztein David C.,Teipel Stefan,Fievet Nathalie,Deramerourt Vincent,Forsell Charlotte,Thonberg Håkan,Bjerke Maria,Roeck Ellen De,Martínez-Larrad María Teresa,Olivar Natividad,Aguilera Nuria,Cano Amanda,Cañabate Pilar,Macias Juan,Maroñas Olalla,Nuñez-Llaves Raúl,Olivé Clàudia,Pelejá Ester,Adarmes-Gómez Astrid D.,Alonso María Dolores,Amer-Ferrer Guillermo,Antequera Martirio,Burguera Juan Andrés,Carrillo Fátima,Carrión-Claro Mario,Casajeros María José,Martinez de Pancorbo Marian,Escuela Rocío,Garrote-Espina Lorena,Gómez-Garre Pilar,Hevilla Saray,Jesús Silvia,Espinosa Miguel Angel Labrador,Legaz Agustina,López-García Sara,Macias-García Daniel,Manzanares Salvadora,Marín Marta,Marín-Muñoz Juan,Marín Tamara,Martínez Begoña,Martínez Victoriana,Martínez-Lage Álvarez Pablo,Iriarte Maite Mendioroz,Periñán-Tocino María Teresa,Pineda-Sánchez Rocío,Real de Asúa Diego,Rodrigo Silvia,Sastre Isabel,Vicente Maria Pilar,Vigo-Ortega Rosario,Vivancos Liliana,Epelbaum Jacques,Hannequin Didier,campion Dominique,Deramecourt Vincent,Tzourio Christophe,Brice Alexis,Dubois Bruno,Williams Amy,Thomas Charlene,Davies Chloe,Nash William,Dowzell Kimberley,Morales Atahualpa Castillo,Bernardo-Harrington Mateus,Turton James,Lord Jenny,Brown Kristelle,Vardy Emma,Fisher Elizabeth,Warren Jason D.,Rossor Martin,Ryan Natalie S.,Guerreiro Rita,Uphill James,Bass Nick,Heun Reinhard,Kölsch Heike,Schürmann Britta,Lacour André,Herold Christine,Johnston Janet A.,Passmore Peter,Powell John,Patel Yogen,Hodges Angela,Becker Tim,Warden Donald,Wilcock Gordon,Clarke Robert,Deloukas Panagiotis,Ben-Shlomo Yoav,Hooper Nigel M.,Pickering-Brown Stuart,Sussams Rebecca,Warner Nick,Bayer Anthony,Heuser Isabella,Drichel Dmitriy,Klopp Norman,Mayhaus 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Arto,Laukkanen Jari,Julkunen Valtteri,Remes Anne,Kälviäinen Reetta,Peltola Jukka,Tienari Pentti,Rinne Juha,Ziemann Adam,Waring Jeffrey,Esmaeeli Sahar,Smaoui Nizar,Lehtonen Anne,Eaton Susan,Lahdenperä Sanni,van Adelsberg Janet,Michon John,Kerchner Geoff,Bowers Natalie,Teng Edmond,Eicher John,Mehta Vinay,Gormley Padhraig,Linden Kari,Whelan Christopher,Xu Fanli,Pulford David,Färkkilä Martti,Pikkarainen Sampsa,Jussila Airi,Blomster Timo,Kiviniemi Mikko,Voutilainen Markku,Georgantas Bob,Heap Graham,Rahimov Fedik,Usiskin Keith,Lu Tim,Oh Danny,Kalpala Kirsi,Miller Melissa,McCarthy Linda,Eklund Kari,Palomäki Antti,Isomäki Pia,Pirilä Laura,Kaipiainen-Seppänen Oili,Huhtakangas Johanna,Lertratanakul Apinya,Hochfeld Marla,Bing Nan,Gordillo Jorge Esparza,Mars Nina,Pelkonen Margit,Kauppi Paula,Kankaanranta Hannu,Harju Terttu,Close David,Greenberg Steven,Chen Hubert,Betts Jo,Ghosh Soumitra,Salomaa Veikko,Niiranen Teemu,Juonala Markus,Metsärinne Kaj,Kähönen Mika,Junttila Juhani,Laakso Markku,Pihlajamäki Jussi,Sinisalo Juha,Taskinen Marja-Riitta,Tuomi Tiinamaija,Challis Ben,Peterson Andrew,Chu Audrey,Parkkinen Jaakko,Muslin Anthony,Joensuu Heikki,Meretoja Tuomo,Aaltonen Lauri,Mattson Johanna,Auranen Annika,Karihtala Peeter,Kauppila Saila,Auvinen Päivi,Elenius Klaus,Popovic Relja,Schutzman Jennifer,Loboda Andrey,Chhibber Aparna,Lehtonen Heli,McDonough Stefan,Crohns Marika,Kulkarni Diptee,Kaarniranta Kai,Turunen Joni A.,Ollila Terhi,Seitsonen Sanna,Uusitalo Hannu,Aaltonen Vesa,Uusitalo-Järvinen Hannele,Luodonpää Marja,Hautala Nina,Loomis Stephanie,Strauss Erich,Chen Hao,Podgornaia Anna,Hoffman Joshua,Tasanen Kaisa,Huilaja Laura,Hannula-Jouppi Katariina,Salmi Teea,Peltonen Sirkku,Koulu Leena,Harvima Ilkka,Wu Ying,Choy David,Pussinen Pirkko,Salminen Aino,Salo Tuula,Rice David,Nieminen Pekka,Palotie Ulla,Siponen Maria,Suominen Liisa,Mäntylä Päivi,Gursoy Ulvi,Anttonen Vuokko,Sipilä Kirsi,Davis Justin Wade,Quarless Danjuma,Petrovski Slavé,Wigmore Eleonor,Chen Chia-Yen,Bronson Paola,Tsai Ellen,Huang Yunfeng,Maranville Joseph,Shaikho Elmutaz,Mohammed Elhaj,Wadhawan Samir,Kvikstad Erika,Caliskan Minal,Chang Diana,Bhangale Tushar,Pendergrass Sarah,Holzinger Emily,Chen Xing,Hedman Åsa,King Karen S.,Wang Clarence,Xu Ethan,Auge Franck,Chatelain Clement,Rajpal Deepak,Liu Dongyu,Call Katherine,Xia Tai-he,Brauer Matt,Kurki Mitja,Karjalainen Juha,Havulinna Aki,Jalanko Anu,Palta Priit,della Briotta Parolo Pietro,Zhou Wei,Lemmelä Susanna,Rivas Manuel,Harju Jarmo,Lehisto Arto,Ganna Andrea,Llorens Vincent,Laivuori Hannele,Rüeger Sina,Niemi Mari E.,Tukiainen Taru,Reeve Mary Pat,Heyne Henrike,Palin Kimmo,Garcia-Tabuenca Javier,Siirtola Harri,Kiiskinen Tuomo,Lee Jiwoo,Tsuo Kristin,Elliott Amanda,Kristiansson Kati,Hyvärinen Kati,Ritari Jarmo,Koskinen Miika,Pylkäs Katri,Kalaoja Marita,Karjalainen Minna,Mantere Tuomo,Kangasniemi Eeva,Heikkinen Sami,Laakkonen Eija,Sipeky Csilla,Heron Samuel,Karlsson Antti,Jambulingam Dhanaprakash,Rathinakannan Venkat 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D.,Cairns Nigel J.,Cao Chuanhai,Carlson Christopher S.,Carlsson Cynthia M.,Carney Regina M.,Carrasquillo Minerva M.,Chasse Scott,Chesselet Marie-Francoise,Chesi Alessandra,Chin Nathaniel A.,Chui Helena C.,Chung Jaeyoon,Craft Suzanne,Crane Paul K.,Cribbs David H.,Crocco Elizabeth A.,Cruchaga Carlos,Cuccaro Michael L.,Cullum Munro,Darby Eveleen,Davis Barbara,De Jager Philip L.,DeCarli Charles,DeToledo John,Dick Malcolm,Dickson Dennis W.,Dombroski Beth A.,Doody Rachelle S.,Duara Ranjan,Ertekin-Taner Nilüfer,Evans Denis A.,Fairchild Thomas J.,Fallon Kenneth B.,Farlow Martin R.,Farrell John J.,Fernandez-Hernandez Victoria,Ferris Steven,Frosch Matthew P.,Fulton-Howard Brian,Galasko Douglas R.,Gamboa Adriana,Gearing Marla,Geschwind Daniel H.,Ghetti Bernardino,Gilbert John R.,Grabowski Thomas J.,Graff-Radford Neill R.,Grant Struan F. A.,Green Robert C.,Growdon John H.,Haines Jonathan L.,Hakonarson Hakon,Hall James,Hamilton Ronald L.,Harari Oscar,Harrell Lindy E.,Haut Jacob,Head Elizabeth,Henderson Victor W.,Hernandez Michelle,Hohman Timothy,Honig Lawrence S.,Huebinger Ryan M.,Huentelman Matthew J.,Hulette Christine M.,Hyman Bradley T.,Hynan Linda S.,Ibanez Laura,Jarvik Gail P.,Jayadev Suman,Jin Lee-Way,Johnson Kim,Johnson Leigh,Kamboh M. Ilyas,Karydas Anna M.,Katz Mindy J.,Kaye Jeffrey A.,Keene C. Dirk,Khaleeq Aisha,Kim Ronald,Knebl Janice,Kowall Neil W.,Kramer Joel H.,Kuksa Pavel P.,LaFerla Frank M.,Lah James J.,Larson Eric B.,Lee Chien-Yueh,Lee Edward B.,Lerner Alan,Leung Yuk Yee,Leverenz James B.,Levey Allan I.,Li Mingyao,Lieberman Andrew P.,Lipton Richard B.,Logue Mark,Lyketsos Constantine G.,Malamon John,Mains Douglas,Marson Daniel C.,Martiniuk Frank,Mash Deborah C.,Masliah Eliezer,Massman Paul,Masurkar Arjun,McCormick Wayne C.,McCurry Susan M.,McDavid Andrew N.,McDonough Stefan,McKee Ann C.,Mesulam Marsel,Mez Jesse,Miller Bruce L.,Miller Carol A.,Miller Joshua W.,Montine Thomas J.,Monuki Edwin S.,Morris John C.,Myers Amanda J.,Nguyen Trung,O’Bryant Sid,Olichney John M.,Ory Marcia,Palmer Raymond,Parisi Joseph E.,Paulson Henry L.,Pavlik Valory,Paydarfar David,Perez Victoria,Peskind Elaine,Petersen Ronald C.,Phillips-Cremins Jennifer E.,Pierce Aimee,Polk Marsha,Poon Wayne W.,Potter Huntington,Qu Liming,Quiceno Mary,Quinn Joseph F.,Raj Ashok,Raskind Murray,Reiman Eric M.,Reisberg Barry,Reisch Joan S.,Ringman John M.,Roberson Erik D.,Rodriguear Monica,Rogaeva Ekaterina,Rosen Howard J.,Rosenberg Roger N.,Royall Donald R.,Sager Mark A.,Sano Mary,Saykin Andrew J.,Schneider Julie A.,Schneider Lon S.,Seeley William W.,Slifer Susan H.,Small Scott,Smith Amanda G.,Smith Janet P.,Song Yeunjoo E.,Sonnen Joshua A.,Spina Salvatore,George-Hyslop Peter St,Stern Robert A.,Stevens Alan B.,Strittmatter Stephen M.,Sultzer David,Swerdlow Russell H.,Tanzi Rudolph E.,Tilson Jeffrey L.,Trojanowski John Q.,Troncoso Juan C.,Tsuang Debby W.,Valladares Otto,Van Deerlin Vivianna M.,van Eldik Linda J.,Vassar Robert,Vinters Harry V.,Vonsattel Jean-Paul,Weintraub Sandra,Welsh-Bohmer Kathleen A.,Whitehead Patrice L.,Wijsman Ellen M.,Wilhelmsen Kirk C.,Williams Benjamin,Williamson Jennifer,Wilms Henrik,Wingo Thomas S.,Wisniewski Thomas,Woltjer Randall L.,Woon Martin,Wright Clinton B.,Wu Chuang-Kuo,Younkin Steven G.,Yu Chang-En,Yu Lei,Zhang Yuanchao,Zhao Yi,Zhu Xiongwei,Adams Hieab,Akinyemi Rufus O.,Ali Muhammad,Armstrong Nicola,Aparicio Hugo J.,Bahadori Maryam,Becker James T.,Breteler Monique,Chasman Daniel,Chauhan Ganesh,Comic Hata,Cox Simon,Cupples Adrienne L.,Davies Gail,DeCarli Charles S.,Duperron Marie-Gabrielle,Dupuis Josée,Evans Tavia,Fan Frank,Fitzpatrick Annette,Fohner Alison E.,Ganguli Mary,Geerlings Mirjam,Glatt Stephen J.,Gonzalez Hector M.,Goss Monica,Grabe Hans,Habes Mohamad,Heckbert Susan R.,Hofer Edith,Hong Elliot,Hughes Timothy,Kautz Tiffany F.,Knol Maria,Kremen William,Lacaze Paul,Lahti Jari,Grand Quentin Le,Litkowski Elizabeth,Li Shuo,Liu Dan,Liu Xuan,Loitfelder Marisa,Manning Alisa,Maillard Pauline,Marioni Riccardo,Mazoyer Bernard,van Lent Debora Melo,Mei Hao,Mishra Aniket,Nyquist Paul,O’Connell Jeffrey,Patel Yash,Paus Tomas,Pausova Zdenka,Raikkonen-Talvitie Katri,Riaz Moeen,Rich Stephen,Rotter Jerome,Romero Jose,Roshchupkin Gena,Saba Yasaman,Sargurupremraj Murali,Schmidt Helena,Schmidt Reinhold,Shulman Joshua M.,Smith Jennifer,Sekhar Hema,Rajula Reddy,Shin Jean,Simino Jeannette,Sliz Eeva,Teumer Alexander,Thomas Alvin,Tin Adrienne,Tucker-Drob Elliot,Vojinovic Dina,Wang Yanbing,Weinstein Galit,Williams Dylan,Wittfeld Katharina,Yanek Lisa,Yang Yunju,Farrer Lindsay A.^ORCID,Psaty Bruce M.^ORCID,Ghanbari Mohsen^ORCID,Raj Towfique^ORCID,Sachdev Perminder^ORCID,Mather Karen^ORCID,Jessen Frank,Ikram M. Arfan^ORCID,de Mendonça Alexandre,Hort Jakub,Tsolaki Magda^ORCID,Pericak-Vance Margaret A.^ORCID,Amouyel Philippe^ORCID,Williams Julie^ORCID,Frikke-Schmidt Ruth^ORCID,Clarimon Jordi,Deleuze Jean-François,Rossi Giacomina,Seshadri Sudha^ORCID,Andreassen Ole A.^ORCID,Ingelsson Martin,Hiltunen Mikko,Sleegers Kristel^ORCID,Schellenberg Gerard D.,van Duijn Cornelia M.^ORCID,Sims Rebecca^ORCID,van der Flier Wiesje M.^ORCID,Ruiz Agustín,Ramirez Alfredo^ORCID,Lambert Jean-Charles^ORCID, , , , , , , , ,

Abstract

AbstractCharacterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

https://www.nature.com/articles/s41588-022-01024-z.pdf

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