Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
Author:
Brouwer Philip J. M.ORCID, Brinkkemper Mitch, Maisonnasse Pauline, Dereuddre-Bosquet Nathalie, Grobben Marloes, Claireaux Mathieu, de Gast Marlon, Marlin Romain, Chesnais Virginie, Diry Ségolène, Allen Joel D.ORCID, Watanabe YasunoriORCID, Giezen Julia M., Kerster Gius, Turner Hannah L., van der Straten Karlijn, van der Linden Cynthia A., Aldon Yoann, Naninck Thibaut, Bontjer Ilja, Burger Judith A., Poniman Meliawati, Mykytyn Anna Z., Okba Nisreen M. A.ORCID, Schermer Edith E., van Breemen Marielle J., Ravichandran RashmiORCID, Caniels Tom G.ORCID, van Schooten Jelle, Kahlaoui Nidhal, Contreras Vanessa, Lemaître Julien, Chapon Catherine, Ho Tsong Fang Raphaël, Villaudy Julien, Sliepen Kwinten, van der Velden Yme U., Haagmans Bart L., de Bree Godelieve J., Ginoux Eric, Ward Andrew B.ORCID, Crispin MaxORCID, King Neil P., van der Werf Sylvie, van Gils Marit J.ORCID, Grand Roger Le, Sanders Rogier W.
Abstract
SummaryThe SARS-CoV-2 pandemic is continuing to disrupt personal lives, global healthcare systems and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits and cynomolgus macaques. The vaccine-induced immunity protected macaques against a high dose challenge, resulting in strongly reduced viral infection and replication in upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic.
Publisher
Cold Spring Harbor Laboratory
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