Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate-Reference-Cited by-同舟云学术

Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate

Published:2020-10-21 Issue:11 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Addetia Amin¹,Crawford Katharine H. D.²³⁴,Dingens Adam²,Zhu Haiying¹,Roychoudhury Pavitra¹⁵,Huang Meei-Li¹⁵,Jerome Keith R.¹⁵,Bloom Jesse D.²³⁶^ORCID,Greninger Alexander L.¹⁵^ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA

2. Division of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

3. Department of Genome Sciences, University of Washington, Seattle, Washington, USA

4. Medical Scientist Training Program, University of Washington, Seattle, Washington, USA

5. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

6. Howard Hughes Medical Institute, Seattle, Washington, USA

Abstract

The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans. However, to date, studies on protective immunity have been performed only in animal models and correlates of protection have not been established in humans. Here, we describe an outbreak of SARS-CoV-2 on a fishing vessel associated with a high attack rate. Predeparture serological and viral reverse transcription-PCR (RT-PCR) testing along with repeat testing after return to shore was available for 120 of the 122 persons on board over a median follow-up of 32.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.02107-20

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