Immunogenicity and Protective Efficacy of a Highly Thermotolerant, Trimeric SARS-CoV-2 Receptor Binding Domain Derivative

Author:

Malladi Sameer Kumar1,Patel Unnatiben Rajeshbhai2,Rajmani Raju S.1,Singh Randhir2,Pandey Suman2,Kumar Sahil3,Khaleeq Sara1,van Vuren Petrus Jansen4,Riddell Shane4,Goldie Sarah4,Gayathri Savitha1,Chakraborty Debajyoti1,Kalita Parismita1,Pramanick Ishika1,Agarwal Nupur2,Reddy Poorvi2,Girish Nidhi2,Upadhyaya Aditya2,Khan Mohammad Suhail1,Kanjo Kawkab1,Bhat Madhuraj2,Mani Shailendra5,Bhattacharyya Sankar5,Siddiqui Samreen6,Tyagi Akansha6,Jha Sujeet6,Pandey Rajesh7,Tripathi Shashank89,Dutta Somnath1,McAuley Alexander J.4,Singanallur Nagendrakumar Balasubramanian4,Vasan Seshadri S.410,Ringe Rajesh P.3,Varadarajan Raghavan1ORCID

Affiliation:

1. Molecular Biophysics Unit (MBU), Indian Institute of Science, Bengaluru 560012, India

2. Mynvax Private Limited, ES12, Entrepreneurship Centre, SID, Indian Institute of Science, Bengaluru 560012, India

3. Virology Unit, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Sector 39-A, Chandigarh 160036, India

4. Australian Centre for Disease Preparedness (ACDP), Commonwealth Scientific and Industrial Research Organisation (CSIRO), 5 Portarlington Road, Geelong 3220, Victoria, Australia

5. Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Third Milestone, Gurugram-Faridabad Expressway, Faridabad 121001, India

6. Max Super Speciality Hospital (A Unit of Devki Devi Foundation), Max Healthcare, Delhi 1100017, India

7. Integrative Genomics of Host-Pathogen (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi 110007, India

8. Department of Microbiology & Cell Biology, Indian Institute of Science, Bengaluru 560012, India

9. Centre for Infectious Disease Research, Indian Institute of Science, Bengaluru 560012, India

10. Department of Health Sciences, University of York, York YO10 5DD, United Kingdom

Funder

Science and Engineering Research Board

National Health and Medical Research Council

Department of Biotechnology , Ministry of Science and Technology

Bill and Melinda Gates Foundation

Fondation Botnar

Govt of India PM CARES fund

CSIR-IGIB grant

CSIROâ??s Precision Health and Responsible Innovation Future Science

Australiaâ??s Department of Finance

CSR-IISc COVID vaccine fund

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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