Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain-Reference-Cited by-同舟云学术

Obesity and hidradenitis suppurativa: targeting meta-inflammation for therapeutic gain

Published:2023-05-12 Issue:9 Volume:48 Page:984-990
ISSN:0307-6938
Container-title:Clinical and Experimental Dermatology
language:en
Short-container-title:

Author:

Mintoff Dillon¹²^ORCID,Agius Rachel³⁴,Benhadou Farida⁵,Das Anupam⁶,Frew John W⁷⁸⁹^ORCID,Pace Nikolai P⁴¹⁰^ORCID

Affiliation:

1. Department of Dermatology

2. Department of Pathology, Faculty of Medicine and Surgery

3. Diabetes and Endocrine Centre, Mater Dei Hospital , Msida , Malta

4. Faculty of Medicine and Surgery

5. Department of Dermatology , Hôpital Erasme, Universite Libre de Bruxelles, Bruxelles , Belgium

6. Department of Dermatology, Venereology and Leprosy; KPC Medical College & Hospital , Kolkata , India

7. Laboratory of Translational Cutaneous Medicine, Ingham Institute for Applied Medical Research , Sydney, NSW , Australia

8. Department of Dermatology, Liverpool Hospital , Sydney, NSW , Australia

9. University of New South Wales , Sydney, NSW , Australia

10. Centre for Molecular Medicine and Biobanking, University of Malta , Msida , Malta

Abstract

Abstract Hidradenitis suppurativa (HS) is a chronic, inflammatory condition of the pilosebaceous unit. The typical patient with HS is characterized as someone with obesity, who smokes and who has nodules, abscesses and/or draining tunnels predominantly distributed in intertriginous skin. It has been established that lifestyle and genetic factors are the main pathophysiological drivers of HS. In this critical review, we explore the interrelatedness of meta-inflammation, obesity and HS and discuss if and how this relationship may be manipulated for a therapeutic end.

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Link

https://academic.oup.com/ced/advance-article-pdf/doi/10.1093/ced/llad182/50830112/llad182.pdf

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1. Association of hidradenitis suppurativa (HS) with waist circumference: A bidirectional two‐sample Mendelian randomization study of HS with metabolic syndrome;The Journal of Dermatology;2024-09-04

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3. Prevalence and association of polycystic ovary syndrome and hidradenitis suppurativa in underrepresented groups;Archives of Dermatological Research;2024-06-08

4. Semaglutide for weight loss in people with obesity as an adjunctive treatment for hidradenitis suppurativa: its impact on disease control and quality of life;British Journal of Dermatology;2024-05-21

5. The NLRP3 Inflammasome Gene Is Overexpressed in Hidradenitis Suppurativa Lesions: A Preliminary Study on the Role of Pyroptosis in Disease Pathogenesis;Current Issues in Molecular Biology;2024-03-16