Implementing Whole-Genome Sequencing for Ongoing Surveillance of Antimicrobial Resistance: Exemplifying Insights Into Klebsiella pneumoniae

Author:

Aanensen David M12,Carlos Celia C3,Donado-Godoy Pilar4,Okeke Iruka N5,Ravikumar K L6,Abudahab Khalil,Abrudan Monica,Argimón Silvia,Harste Harry,Kekre Mihir,Muddyman Dawn,Taylor Ben,Underwood Anthony,Wheeler Nicole,David Sophia,Fabian Bernal Johan,Arevalo Alejandra,Fernanda Valencia Maria,Osma Castro Erik C D,Nagaraj Geetha,Shamanna Varun,Govindan Vandana,Prabhu Akshata,Sravani D,Shincy M R,Rose Steffimole,Ravishankar K N,Oaikhena Anderson O,Afolayan Ayorinde O,Ajiboye Jolaade J,Ewomazino Odih Erkison,Lagrada Marietta L,Macaranas Polle Krystle V,Olorosa Agnettah M,Gayeta June M,Herrera Elmer M,Molloy Ali,Vegvari Carolin,

Affiliation:

1. Centre  for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford, Old Road Campus, Oxford, United Kingdom

2. Wellcome Genome Campus, Hinxton, United Kingdom

3. Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine, Muntinlupa, Philippines

4. Colombian Integrated Program for Antimicrobial Resistance Surveillance–Coipars, CI Tibaitatá, Corporación Colombiana de Investigación Agropecuaria, Tibaitatá–Mosquera, Cundinamarca, Colombia

5. Global Health Research Unit for the Genomic Surveillance of Antimicrobial Resistance, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Oyo State, Nigeria

6. Central Research Laboratory, Kempegowda Institute of Medical Sciences, Bengaluru, India

Abstract

Abstract In this Supplement, we detail outputs of the National Institute for Health Research Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance project, covering practical implementation of whole-genome sequencing across our consortium, which consists of laboratories in Colombia, India, Nigeria, and the Philippines.

Funder

National Institute for Health Research

Department for International Development, UK Government

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference12 articles.

1. Whole-genome sequencing as part of national and international surveillance programmes for antimicrobial resistance: a roadmap;National Institute for Health Research Global Health Research Unit on Genomic Surveillance of AMR.;BMJ Glob Health,2020

2. Integrating scalable genome sequencing into microbiology laboratories for routine AMR surveillance;Kekre;Clin Infect Dis,2021

3. Overcoming data bottlenecks in genomic pathogen surveillance;Afolayan;Clin Infect Dis,2021

4. Train-the-trainer as an effective approach to building global networks of experts in genomic surveillance of AMR;Abrudan;Clin Infect Dis,2021

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