Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning

Author:

Shameer Khader1,Glicksberg Benjamin S2,Hodos Rachel23,Johnson Kipp W2,Badgeley Marcus A2,Readhead Ben1,Tomlinson Max S1,O’Connor Timothy4,Miotto Riccardo1,Kidd Brian A1,Chen Rong5,Ma’ayan Avi6,Dudley Joel T1789

Affiliation:

1. Institute of Next Generation Healthcare, Mount Sinai Health System, New York, NY, USA

2. Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, NY, USA

3. New York University, New York, NY, USA

4. Boston College, Boston, MA, USA

5. Clinical Genome Informatics, Icahn Institute of Genetics and Multiscale Biology, Mount Sinai Health System, New York, NY

6. Mount Sinai Center for Bioinformatics, Mount Sinai Health System, New York, NY

7. Department of Genetics and Genomic Sciences, Mount Sinai Health System, New York, NY, USA

8. Department of Population Health Science and Policy, Mount Sinai Health System, New York, NY, USA

9. Director of Biomedical Informatics, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, NY

Funder

National Institutes of Health

National Institute of Diabetes and Digestive and Kidney Diseases

National Cancer Institute

Illuminating the Druggable Genome

National Center for Advancing Translational Sciences

Clinical and Translational Science Awards

Publisher

Oxford University Press (OUP)

Subject

Molecular Biology,Information Systems

Reference122 articles.

1. Biomarker tests for molecularly targeted therapies–the key to unlocking precision medicine;Lyman;N Engl J Med,2016

2. A new initiative on precision medicine;Collins;N Engl J Med,2015

3. Preparing for precision medicine;Mirnezami;N Engl J Med,2012

4. Harnessing big data for systems pharmacology;Xie;Annu Rev Pharmacol Toxicol,2016

5. Computational and experimental advances in drug repositioning for accelerated therapeutic stratification;Shameer;Curr Top Med Chem,2015

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