More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand-Reference-Cited by-同舟云学术

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More is not always better: finding the right trade-off between affinity and selectivity of a G-quadruplex ligand

Published:2018-07-09 Issue:19 Volume:46 Page:e115-e115
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Zuffo Michela¹,Guédin Aurore²,Leriche Emma-Dune²,Doria Filippo¹,Pirota Valentina¹,Gabelica Valérie²,Mergny Jean-Louis²³,Freccero Mauro¹^ORCID

Affiliation:

1. Dipartimento di Chimica, Università di Pavia, Pavia 27100, Italy

2. ARNA Laboratory, Université de Bordeaux, Inserm U1212, CNRS UMR5320, Institut Européen de Chimie Biologie (IECB), Pessac 33607, France

3. Institute of Biophysics, AS CR, Brno 61265, Czech Republic

Funder

European Research Council

Italian Association for Cancer Research

European Regional Development Fund

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/46/19/e115/26331788/gky607.pdf

Reference59 articles.

1. DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential;Hänsel-Hertsch;Nat. Rev. Mol. Cell. Biol.,2017

2. Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes;Huppert;Chem. Soc. Rev.,2008

3. Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability

4. Metal cations in G-Quadruplex folding and stability;Bhattacharyya;Front. Chem.,2016

5. Different loop arrangements of intramolecular human telomeric (3+1) G-quadruplexes in K+ solution;Phan;Nucleic Acids Res.,2006

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