1. Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA 2Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, 87131, USA 3Ragon Institute of MGH, MIT and Harvard, Boston, MA, 02129 USA, 4Department of Pediatrics, University of Tennessee School of Medicine, 5LeBonheur Children's Medical Center, 6The Children's Foundation Research Center and 7Department of Molecular Sciences, University of Tennessee Graduate School of Health Sciences, Memphis, TN, 38103 USA