Ascorbic acid interference in reagent-strip reactions for assay of urinary glucose and hemoglobin.

Author:

Zweig M H,Jackson A

Abstract

Abstract Vitamin C (ascorbic acid), commonly taken as a dietary supplement and excreted in the urine, can interfere with peroxidase redox indicator systems such as those used in reagent-strip tests for urinary glucose and hemoglobin. We investigated whether the concentrations of ascorbic acid in urine after modest supplementary doses of vitamin C are high enough to interfere with such dipstick tests. After adding glucose or hemoglobin to urine collected from persons not taking vitamin C and from persons taking 350 to 1000 mg of vitamin C daily, we tested four reagent strips for interference and found that these commonly taken doses did frequently interfere with all test systems examined.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

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1. Pitfalls in the diagnosis of hematuria;Clinical Chemistry and Laboratory Medicine (CCLM);2023-04-24

2. Performance evaluation of Hipee S2 point-of-care testing urine dipstick analyser: a cross-sectional study;BMJ Open;2022-10

3. Activity‐Based Sensing of Ascorbate by Using Copper‐Mediated Oxidative Bond Cleavage;Chemistry – A European Journal;2020-06-25

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