Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms-Reference-Cited by-同舟云学术

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

Published:2001-11 Issue:11 Volume:2 Page:1029-1034
ISSN:1469-221X
Container-title:EMBO reports
language:en
Short-container-title:EMBO Rep

Author:

Stad Robert¹,Little Natalie A¹,Xirodimas Dimitris P²,Frenk Ruth¹,van der Eb Alex J¹,Lane David P²,Saville Mark K²,Jochemsen Aart G¹

Affiliation:

1. Leiden University Medical Centre, Department of Molecular and Cell Biology and Centre for Biomedical Genetics, PO Box 9503 2300 RA Leiden The Netherlands

2. University of Dundee, Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School Dundee DD1 9SY UK

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1093/embo-reports/kve227

Reference16 articles.

1. The contribution of the acidic domain of MDM2 to p53 and MDM2 stability

2. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53

3. Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

4. The MDM2 RING-finger domain is required to promote p53 nuclear export

5. Mdm2 promotes the rapid degradation of p53

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