Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein–Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy-Reference-Cited by-同舟云学术

Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein–Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy

Published:2023-12-07 Issue:24 Volume:66 Page:16991-17025
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cheng Jing¹²,Yan Ziqin¹,Jiang Kailong³,Liu Chen¹⁴,Xu Dehua³⁵,Lyu Xilin¹,Hu Xiaobei³,Zhang Shiyan¹²,Zhou Yubo¹³,Li Jia¹³⁵,Zhao Yujun¹²⁴⁶⁷^ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, P. R. China

2. University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, P. R. China

3. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, P. R. China

4. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, P. R. China

5. School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124000, P. R. China

6. Shandong Provincial Key Laboratory of Biopharmaceuticals, Shandong Academy of Pharmaceutical Sciences, Jinan 250101, P. R. China

7. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, P. R. China

Funder

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Jinan Innovation Team Project

Guangdong High-level New Research and Development Institute

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica,Chinese Academy of Sciences

Guangdong High-level Innovative Research Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01815

Reference84 articles.

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2. MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity

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4. Drugging the p53 pathway: understanding the route to clinical efficacy

5. Drugging p53 in cancer: one protein, many targets