Cefiderocol: A Novel Siderophore Cephalosporin Defeating Carbapenem-resistant Pathogens-Reference-Cited by-同舟云学术

Cefiderocol: A Novel Siderophore Cephalosporin Defeating Carbapenem-resistant Pathogens

Published:2019-11-13 Issue:Supplement_7 Volume:69 Page:S519-S520
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Bonomo Robert A¹²³

Affiliation:

1. Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio

2. Departments of Medicine, Pharmacology, Molecular Biology and Microbiology, Biochemistry, and Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio

3. CWRU-Cleveland VAMC (Case VA CARES), Cleveland, Ohio

Abstract

AbstractCefiderocol, a novel siderophore cephalosporin in late-stage clinical development, utilizes a “Trojan horse” active transport mechanism to enter bacteria and has proven in vitro activity against carbapenem-resistant gram-negative pathogens, including those with major carbapenem-resistance mechanisms, and stability against all carbapenemases.

Funder

Shionogi & Co, Ltd

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/article-pdf/69/Supplement_7/S519/30678450/ciz823.pdf

Reference25 articles.

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3. Association between carbapenem resistance and mortality among adults hospitalized with serious infections due to an Enterobacteriaceae spp: results of a systematic literature review and meta-analysis;Martin;Open Forum Infect Dis,2018