Therapies for multidrug resistant and extensively drug-resistant non-fermenting gram-negative bacteria causing nosocomial infections: a perilous journey toward ‘molecularly targeted’ therapy

Author:

El Chakhtoura Nadim G.123,Saade Elie1234,Iovleva Alina5,Yasmin Mohamad124,Wilson Brigid123,Perez Federico123,Bonomo Robert A.12346

Affiliation:

1. Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA

2. Research Services, Department of Internal Medicine, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA

3. Geriatrics Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA

4. Department of Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA

5. Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

6. Departments of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA

Funder

Cleveland Department of Veterans Affairs

National Institute of Allergy and Infectious Diseases of the National Institutes of Health

Antibiotic Resistance Leadership Group under National Institutes of Health

the Clinical and Translational Science Collaborative of Cleveland

National Center for Advancing Translational Sciences

Publisher

Informa UK Limited

Subject

Virology,Infectious Diseases,Microbiology (medical),Microbiology

Reference193 articles.

1. U.S. Department of Health and Human Services, CDC [Internet]. Antibiotic Resistance Threats in the United States. Atlanta (GA): CDC; 2013 [cited 2017 Dec 26]. Available from: http://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf

2. The Review on Antimicrobial Resistance [Internet]. Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. London (UK): O’neill J. 2016 [cited 2017 Dec 26]. Available from: https://amr-review.org

3. World Health Organization (WHO) [Internet]. Draft global action plan on antimicrobial resistance. Geneva (Switzerland): WHO; 2015 [cited 2017 Dec 26]. Available from: http://apps.who.int/iris/bitstream/10665/193736/1/9789241509763_eng.pdf?ua=1

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