Phenobarbital and Phenytoin Increased Acetaminophen Hepatotoxicity Due to Inhibition of UDP-Glucuronosyltransferases in Cultured Human Hepatocytes

Author:

Kostrubsky Seva E.,Sinclair Jacqueline F.,Strom Stephen C.,Wood Sheryl,Urda Ellen,Stolz Donna Beer,Wen Yuan H.,Kulkarni Shaila,Mutlib Abdul

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference33 articles.

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2. Bray, G. P., Harrison, P. M., O'Grady, J. G., Tredger, M. J., and Williams, R. (1992). Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure. Hum. Exp. Toxicol.11,265–270.

3. Court, M., Duan, S., Moltke, L., Greenblatt, D., Patten, J., Miners, J., and Mackenzie, P. (2001). Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP-glucuronosyltransferase isoform. J. Pharmacol. Exp. Ther.299,998–1006.

4. Court, M., and Greenblatt, J. (1997). Biochemical basis for deficient paracetamol glucuronidation in cats: An interspecies comparison of enzyme constraint in liver microsomes. J. Pharm. Pharmacol.48,446–449.

5. Cummings, J., Ethell, B. T., Jardine, L., Boyd, G., Macpherson, J., and Burchell, B. (2003). Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: Reversal of resistance by food additives. Cancer Res.63,8443–8450.

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