Abstract
Because of the widespread acetaminophen usage and the danger of harmful overdosing effects, developing appropriate procedures for its quantitative and qualitative assay has always been an intriguing and fascinating problem. A quick, inexpensive, and environmentally friendly approach based on direct voltage anodic graphite rod exfoliation in the presence of inorganic salt aqueous solution ((NH4)2SO4–0.3 M) has been established for the preparation of nitrogen-doped graphene (exf-NGr). The XRD analysis shows that the working material appears as a mixture of few (76.43%) and multi-layers (23.57%) of N-doped graphenes. From XPS, the C/O ratio was calculated to be 0.39, indicating a significant number of structural defects and the existence of multiple oxygen-containing groups at the surface of graphene sheets caused by heteroatom doping. Furthermore, the electrochemical performances of glassy carbon electrodes (GCEs) modified with exf-NGr for acetaminophen (AMP) detection and quantification have been assessed. The exf-NGr/GCE-modified electrode shows excellent reproducibility, stability, and anti-interfering characteristics with improved electrocatalytic activity over a wide detection range (0.1–100 µM), with a low limit for AMP detection (LOD = 3.03 nM). In addition, the developed sensor has been successfully applied in real sample analysis for the AMP quantification from different commercially available pharmaceutical formulations.
Funder
Ministry of Research, Innovation and Digitization, CNCS/CCCDI—UEFISCDI
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference87 articles.
1. Acetaminophen for Chronic Pain: A Systematic Review on Efficacy;Basic Clin. Pharmacol. Toxicol.,2016
2. Pharmacologic basis for using paracetamol: Pharmacokinetic and pharmacodynamic issues;Drugs,2003
3. PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses;Pharmacogenet. Genom.,2015
4. A review of acetaminophen poisoning;Crit. Care Clin.,2012
5. Acetaminophen Poisoning;Crit. Care Clin.,2021
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