Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

Author:

Nichols John1,Fay Kellie23ORCID,Bernhard Mary Jo4,Bischof Ina5,Davis John6,Halder Marlies7,Hu Jing6,Johanning Karla8,Laue Heike9,Nabb Diane10,Schlechtriem Christian5,Segner Helmut11,Swintek Joe12,Weeks John13,Embry Michelle14

Affiliation:

1. ORD, NHEERL, Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, Minnesota

2. Biology Department, University of Minnesota, Duluth, Minnesota, 55804

3. CSRA Inc, Duluth, Minnesota

4. The Procter & Gamble Company, Cincinnati, Ohio, 45040

5. Fraunhofer Institute for Molecular Biology and Applied Ecology, Schmallenberg, Germany, 57392

6. The Dow Chemical Company, Midland, Michigan, 48674

7. European Commission, Joint Research Centre, Ispra, Italy, I-21027

8. KJ Scientific, Georgetown, Texas, 78626

9. Givaudan Schweiz AG, Dübendorf, Switzerland, 8600

10. DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware

11. Centre for Fish and Wildlife Health, University of Bern, Bern, Switzerland, 3001

12. Badger Technical Services, Duluth, Minnesota, 55804

13. Weeks Entox, Knoxville, Tennessee, 37931

14. Health and Environmental Sciences Institute, Washington, District of Columbia 20005

Funder

HESI

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference53 articles.

1. A generic QSAR for assessing the bioaccumulation potential of organic chemicals in aquatic food webs;Arnot;QSAR Comb. Sci,2003

2. A food web bioaccumulation model for organic chemicals in aquatic ecosystems;Arnot;Environ. Toxicol. Chem,2004

3. Hepatocytes as in vitro test system to investigate metabolite patterns of pesticides in farmed rainbow trout and common carp: Comparison between in vivo and in vitro and across species;Bischof;Comp. Biochem. Physiol,2016

4. Cross-species extrapolation of uptake and disposition of neutral organic chemicals in fish using a multispecies physiologically-based toxicokinetic model framework;Brinkman;Environ. Sci. Technol,2016

5. Which molecular features affect the intrinsic hepatic clearance rate of ionizable chemicals in fish?;Chen;Environ. Sci. Technol,2016

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