Principal Component Analysis to Distinguish Seizure Liability of Drugs in Human iPS Cell-Derived Neurons
Author:
Affiliation:
1. Department of Electronics, Graduate School of Engineering, Tohoku Institute of Technology, Sendai, Miyagi 982-8577, Japan
2. Drug Safety Research Labs, Astellas Pharma Inc., Tsukuba, Ibaraki 305-8585, Japan
Abstract
Funder
Collaborative project with Astellas Pharma Inc
Publisher
Oxford University Press (OUP)
Subject
Toxicology
Link
http://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfab116/41065438/kfab116.pdf
Reference43 articles.
1. Seizure liability assessments using the hippocampal tissue slice: Comparison of non-clinical species;Accardi;J. Pharmacol. Toxicol. Methods,2018
2. Electrical responses and spontaneous activity of human iPS-derived neuronal networks characterized for 3-month culture with 4096-electrode arrays;Amin;Front. Neurosci,2016
3. Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease;Balez;Sci. Rep,2016
4. Spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays;Black;Front. Cell. Neurosci,2017
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