Is Parkinson’s disease a lysosomal disorder?

Author:

Klein Andrés D1,Mazzulli Joseph R2

Affiliation:

1. Centro de Genética y Genómica, Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Avenida Las Condes 12461, Santiago 7590943, Chile

2. The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Ward 12-369, Chicago, IL, 60611, USA

Funder

Fondo Nacional de Desarrollo Científico y Tecnológico

European Union’s Horizon 2020

Marie Skłodowska-Curie

National Institute of Neurological Disorders and Stroke

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

Reference81 articles.

1. Chaperone-mediated autophagy markers in Parkinson disease brains;Alvarez-Erviti;Arch Neurol,2010

2. Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy;Bar-On;J Neurochem,2006

3. The function of α-synuclein;Bendor;Neuron,2013

4. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization;Bosco;Nat Chem Biol,2006

5. Neuropathological staging of brain pathology in sporadic Parkinson’s disease: separating the wheat from the chaff;Braak;J Parkinsons Dis,2017

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