Insulin-like Growth Factor 2 (IGF2)-Fused Lysosomal Targeting Chimeras for Degradation of Extracellular and Membrane Proteins

Author:

Zhang Bei1,Brahma Rajeev Kungur2,Zhu Liquan1,Feng Jiayi1,Hu Shiqi1,Qian Linghui3ORCID,Du Shubo4,Yao Shao Q.2ORCID,Ge Jingyan1

Affiliation:

1. Key Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310014, China

2. Department of Chemistry, National University of Singapore, 4 Science Drive 2, Singapore, 117544, Singapore

3. Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Cancer Center, & Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310058, China

4. School of Bioengineering, Dalian University of Technology, Dalian, 116024, China

Funder

Ministry of Education - Singapore

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference71 articles.

1. Tissue-based map of the human proteome

2. The matrix in cancer

3. Extracellular protein homeostasis in neurodegenerative diseases

4. Drugging Membrane Protein Interactions

5. The Antibody Society. Therapeutic monoclonal antibodies approved or in review in the EU or US. www.antibodysociety.org/resources/approved-antibodies (accessed August 10, 2023).

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