Tissue-based map of the human proteome-Reference-Cited by-同舟云学术

Tissue-based map of the human proteome

Published:2015-01-23 Issue:6220 Volume:347 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Uhlén Mathias¹²³,Fagerberg Linn¹,Hallström Björn M.¹²,Lindskog Cecilia⁴,Oksvold Per¹,Mardinoglu Adil⁵,Sivertsson Åsa¹,Kampf Caroline⁴,Sjöstedt Evelina¹⁴,Asplund Anna⁴,Olsson IngMarie⁴,Edlund Karolina⁶,Lundberg Emma¹,Navani Sanjay⁷,Szigyarto Cristina Al-Khalili²,Odeberg Jacob¹,Djureinovic Dijana⁴,Takanen Jenny Ottosson²,Hober Sophia²,Alm Tove¹,Edqvist Per-Henrik⁴,Berling Holger²,Tegel Hanna²,Mulder Jan⁸,Rockberg Johan²,Nilsson Peter¹,Schwenk Jochen M.¹,Hamsten Marica²,von Feilitzen Kalle¹,Forsberg Mattias¹,Persson Lukas¹,Johansson Fredric¹,Zwahlen Martin¹,von Heijne Gunnar⁹,Nielsen Jens³⁵,Pontén Fredrik⁴

Affiliation:

1. Science for Life Laboratory, KTH—Royal Institute of Technology, SE-171 21 Stockholm, Sweden.

2. Department of Proteomics, KTH—Royal Institute of Technology, SE-106 91 Stockholm, Sweden.

3. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 Hørsholm, Denmark.

4. Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden·

5. Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.

6. Leibniz Research Centre for Working Environment and Human Factors (IfADo) at Dortmund TU, D-44139 Dortmund, Germany.

7. Lab Surgpath, Mumbai, India.

8. Science for Life Laboratory, Department of Neuroscience, Karolinska Institute, SE-171 77 Stockholm, Sweden.

9. Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.

Abstract

Protein expression across human tissues Sequencing the human genome gave new insights into human biology and disease. However, the ultimate goal is to understand the dynamic expression of each of the approximately 20,000 protein-coding genes and the function of each protein. Uhlén et al. now present a map of protein expression across 32 human tissues. They not only measured expression at an RNA level, but also used antibody profiling to precisely localize the corresponding proteins. An interactive website allows exploration of expression patterns across the human body. Science , this issue 10.1126/science.1260419

Funder

Knut and Alice Wallenberg Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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