Measurement of plasma 5-fluorouracil by high-performance liquid chromatography with comparison of results to tissue drug levels observed using in vivo 19F magnetic resonance spectroscopy in patients on a protracted venous infusion with or without interferon-α

Author:

Findlay M.P.N.,Raynaud F.,Cunningham D.,Iveson A.,Collins D.J.,Leach M.O.

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference23 articles.

1. Phase I study of protracted venous infusion of 5-fluorouracil;Lokich;Cancer,1981

2. Reevaluation of the maximum tolerated dose of continuous venous infusion of 5-fluorouracil with pharmacokinetics;Spicer;Cancer Res,1988

3. Relationship between di-hydropyrimidine dehydrogenase activity and plasma 5-fluor-ouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion;Harris;Cancer Res,1990

4. Phase I trial of low-dose, prolonged continuous infusion fluorouracil plus interferon-alfa: Evidence for enhanced fluorouracil toxicity without pharmacokinetic perturbation;Sparano;J Clin Oncol,1993

5. Determination of 5-fluorouracil and its main metabolites in plasma by high-per-formance liquid chromatography;Barberi-Heyob;J Chromotogr,1992

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