Long-term resistance to 5-fluorouracil promotes epithelial–mesenchymal transition, apoptosis evasion, autophagy, and reduced proliferation rate in colon cancer cells

Author:

Sousa-Squiavinato Annie Cristhine Moraes,Arregui Ramos Diego Alfonso,Wagner Mônica Silveira,Tessmann Josiane Weber,de-Freitas-Junior Julio Cesar Madureira,Morgado-Díaz Jose AndrésORCID

Funder

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Instituto Nacional do Câncer, Ministério da Saúde

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Elsevier BV

Subject

Pharmacology

Reference45 articles.

1. Establishment of drug-resistant cell lines as a model in experimental oncology: a review;Amaral;Anticancer Res.,2019

2. 5-Fluorouracil resistance mechanisms in colorectal cancer: from classical pathways to promising processes;Blondy;Cancer Sci.,2020

3. Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan;Boyer;Clin. Cancer Res.,2004

4. Mismatch repair proficiency and in vitro response to 5-fluorouracil;Carethers;Gastroenterology,1999

5. Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil;de Angelis;Int. J. Oncol.,2004

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