1. CRIBI Biotechnology Center, 2Department of Biology, University of Padova, via U. Bassi 58/B, 35121 Padova, Italy, 3Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, OX1 3TG, UK and 4Department of Statistical Science, University of Padova, via C. Battisti 241, Padova, Italy