Affiliation:
1. Rutgers University, Department of Biochemistry and Microbiology, New Brunswick, NJ 08903-0231
Abstract
Abstract
A reversed-phase liquid chromatographic (LC) system with photodiode array detection was used to analyze chlorophyllin copper complex (CCC). Analysis revealed significant differences in the porphyrin compositions of CCC samples from 5 industrial sources. Copper isochlorin e4 was identified as a major component in most commercial materials. Copper complexes of chlorin e6 and pheophorbide a and unidentified porphyrins with either chlorin- or non-chlorin-type spectra were found in some samples. The variability of porphyrin compositions in commercial preparations may affect the medicinal efficacy of CCC; therefore, analysis of porphyrin composition is important for CCC quality control.
Publisher
Oxford University Press (OUP)
Subject
Pharmacology,Agronomy and Crop Science,Environmental Chemistry,Food Science,Analytical Chemistry