Evaluation of Commercial Chlorophyllin Copper Complex Preparations by Liquid Chromatography with Photodiode Array Detection

Author:

Chernomorsky Simon1,Rancourt Raymond1,Sahai Divya1,Poretz Ronald1

Affiliation:

1. Rutgers University, Department of Biochemistry and Microbiology, New Brunswick, NJ 08903-0231

Abstract

Abstract A reversed-phase liquid chromatographic (LC) system with photodiode array detection was used to analyze chlorophyllin copper complex (CCC). Analysis revealed significant differences in the porphyrin compositions of CCC samples from 5 industrial sources. Copper isochlorin e4 was identified as a major component in most commercial materials. Copper complexes of chlorin e6 and pheophorbide a and unidentified porphyrins with either chlorin- or non-chlorin-type spectra were found in some samples. The variability of porphyrin compositions in commercial preparations may affect the medicinal efficacy of CCC; therefore, analysis of porphyrin composition is important for CCC quality control.

Publisher

Oxford University Press (OUP)

Subject

Pharmacology,Agronomy and Crop Science,Environmental Chemistry,Food Science,Analytical Chemistry

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