Multiple introductions and country-wide spread of DENV-2 genotype II (Cosmopolitan) in Brazil-Reference-Cited by-同舟云学术

Multiple introductions and country-wide spread of DENV-2 genotype II (Cosmopolitan) in Brazil

Published:2023-07-01 Issue:2 Volume:9 Page:
ISSN:2057-1577
Container-title:Virus Evolution
language:en
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Author:

Gräf Tiago¹^ORCID,Ferreira Caroline Do Nascimento¹,de Lima Gustavo Barbosa²,de Lima Raul Emídio²,Machado Lais Ceschini³⁴,Campos Tulio de Lima⁴,Schemberger Michelle Orane⁵,Faoro Helisson⁵,Paiva Marcelo Henrique Santos⁶,Bezerra Matheus Filgueira⁷,Nascimento Valdinete⁸,Souza Victor⁸,Nascimento Fernanda⁸,Mejía Matilde⁸,Silva Dejanane⁸,de Oliveira Yasmin Silva⁸,Gonçalves Luciana⁸⁹,Ramos Tatyana Costa Amorim⁹,de Castro Daniel Barros⁹^ORCID,Arcanjo Ana Ruth¹⁰,Dantas Herton Augusto Pinheiro¹¹,Presibella Mayra Marinho¹²,Fernandes Sandra Bianchini¹³,Gregianini Tatiana Schaffer¹⁴,Paz E Silva Keilla Maria¹⁵,Sacchi Claudio Tavares¹⁶,Cruz Ana Cecília Ribeiro¹⁷¹⁸,Duarte dos Santos Claudia Nunes¹,Bispo de Filippis Ana Maria¹⁹,Bello Gonzalo¹⁹,Wallau Gabriel Luz³⁴²⁰^ORCID,Salvato Richard Steiner¹⁴,Naveca Felipe⁸¹⁹

Affiliation:

1. Laboratório de Virologia Molecular, Instituto Carlos Chagas , Fundação Oswaldo Cruz, Curitiba 81350-010, Brazil

2. Núcleo de Plataformas Tecnológicas (NPT), Instituto Aggeu Magalhães (IAM), FIOCRUZ-Pernambuco , Recife, Pernambuco 50740-465, Brazil

3. Departamento de Entomologia, Instituto Aggeu Magalhães (IAM)-Fundação Oswaldo Cruz-FIOCRUZ , Recife, Pernambuco 50670-420, Brazil

4. Núcleo de Bioinformática (NBI), Instituto Aggeu Magalhães (IAM), FIOCRUZ-Pernambuco , Recife, Pernambuco 50740-465, Brazil

5. Laboratório de Ciências e Tecnologias Aplicadas em Saúde, Instituto Carlos Chagas , Fundação Oswaldo Cruz, Curitiba 81350-010, Brazil

6. Núcleo de Ciências da Vida, Universidade Federal de Pernambuco (UFPE) , Centro Acadêmico do Agreste-Rodovia BR-104, km 59-Nova Caruaru, Caruaru 55002-970, Brazil

7. Departamento de Microbiologia, Instituto Aggeu Magalhães (IAM) , FIOCRUZ-Pernambuco, Recife, Pernambuco 50740-465, Brazil

8. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz , Manaus 69057-070, Brazil

9. Fundação de Vigilância em Saúde do Amazonas—Dra Rosemary Costa Pinto , Manaus, Amazonas 69093-018, Brazil

10. Laboratório Central de Saúde Pública do Amazonas (LACEN-AM) , Manaus, Amazonas 69020-040, Brazil

11. Laboratório de Fronteira de Tabatinga (LAFRON-AM) , Tabatinga, Amazonas 69640-000, Brazil

12. Laboratório Central de Saúde Pública do Estado do Paraná (LACEN-PR) , São José dos Pinhais, Paraná 83060-500, Brazil

13. Laboratório Central de Saúde Pública do Estado de Santa Catarina (LACEN-SC) , Florianópolis, Santa Catarina 88010-001, Brazil

14. Laboratório Central de Saúde Pública do Rio Grande do Sul (LACEN-RS) , Porto Alegre, Rio Grande do Sul 90610-000, Brazil

15. Laboratório Central de Saúde Pública de Pernambuco (LACEN-PE) , Recife, Pernambuco 50050-210, Brazil

16. Laboratorio Estrategico, Instituto Adolfo Lutz (IAL) , Sao Paulo 01246-902, Brazil

17. Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health and Environment Surveillance Secretariat, Ministry of Health , Ananindeua, Para 670030-000, Brazil

18. Institute of Biological Sciences, Federal University of Pará , Belém, Para 66075-110, Brazil

19. Laboratório de Arbovírus e Vírus Hemorrágicos, Instituto Oswaldo Cruz, Fiocruz , Rio de Janeiro 21040-360, Brazil

20. Department of Arbovirology, Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, National Reference Center for Tropical Infectious Diseases , Bernhard-Nocht-Straße 74, Hamburg 20359, Germany

Abstract

Abstract Dengue virus serotype 2, genotype Cosmopolitan (DENV-2-GII), is one of the most widespread DENV strains globally. In the USA, DENV-2 epidemics have been dominated by DENV-2 genotype Asian-American (DENV-2-GIII), and the first cases of DENV-2-GII were only described in 2019, in Peru, and in 2021 in Brazil. To gain new information about the circulation of DENV-2-GII in Brazil, we sequenced 237 DENV-2 confirmed cases sampled between March 2021 and March 2023 and revealed that DENV-2-GII is already present in all geographic regions of Brazil. The phylogeographic analysis inferred that DENV-2-GII was introduced at least four times in Brazil, between May 2020 and August 2022, generating multiple clades that spread throughout the country with different success. Despite multiple introductions of DENV-2-GII, analysis of the country-wide laboratory surveillance data showed that the Brazilian dengue epidemic in 2022 was dominated by DENV-1 in most states. We hypothesize that massive circulation of DENV-2-GIII in previous years in Brazil might have created a population immune barrier against symptomatic homotypic reinfections by DENV-2-GII, leading to sustained cryptic circulation in asymptomatic cases and localized outbreaks of this new genotype. In summary, our study stresses the importance of arboviral genomic surveillance to close monitoring and better understanding the potential impact of DENV-2-GII in the coming years.

Publisher

Oxford University Press (OUP)

Subject

Virology,Microbiology

Link

https://academic.oup.com/ve/advance-article-pdf/doi/10.1093/ve/vead059/51786890/vead059.pdf

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