NSD3 keeps IRF3 active-Reference-Cited by-同舟云学术

NSD3 keeps IRF3 active

Published:2017-11-20 Issue:12 Volume:214 Page:3475-3476
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Mino Takashi¹,Takeuchi Osamu¹

Affiliation:

1. Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan; Japan Agency for Medical Research and Development–Core Research for Evolutional Medical Science and Technology (AMED-CREST), Tokyo, Japan

Abstract

In this issue of JEM, Wang et al. (https://doi.org/10.1084/jem.20170856) show a novel antiviral innate mechanism by which methyltransferase NSD3 directly monomethylates a transcription factor IRF3 and maintains IRF3 phosphorylation to enhance its transcriptional activity, consequently promoting antiviral innate immune responses.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/214/12/3475/1166841/jem_20171980.pdf

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