I SPI1 something needed for B cells-Reference-Cited by-同舟云学术

I SPI1 something needed for B cells

Published:2021-05-12 Issue:7 Volume:218 Page:
ISSN:0022-1007
Container-title:Journal of Experimental Medicine
language:en
Short-container-title:

Author:

Wahlster Lara¹²³^ORCID,Sankaran Vijay G.¹²³^ORCID

Affiliation:

1. Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA

2. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

3. Broad Institute of MIT and Harvard, Cambridge, MA

Abstract

In this issue, Le Coz et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201750) describe a novel immunodeficiency syndrome caused by mutations in SPI1. Through a series of in-depth studies, the authors provide insights into how SPI1 affects blood lineage specification, highlighting the important role of master transcription factors as cellular fate determinants.

Publisher

Rockefeller University Press

Subject

Immunology,Immunology and Allergy

Link

http://rupress.org/jem/article-pdf/doi/10.1084/jem.20210572/1415186/jem_20210572.pdf

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