Affiliation:
1. Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China
2. Tianjin Institute of Animal Sciences, Tianjin, China
3. Xinjiang Academy of Agricultural and Reclamation Sciences, Xinjiang, China
Abstract
The pituitary is a vital endocrine organ that regulates animal seasonal reproduction by controlling the synthesis and secretion of the hormone. The change of photoperiod is the key factor affecting the function of the pituitary in animals, but the mechanism is unclear. Here, we studied the transcriptomic variation in pars distalis (PD) of the pituitary between short photoperiod (SP) and long photoperiod (LP) using RNA sequencing based on the OVX+E2 sheep. 346 differentially expressed (DE) lncRNAs and 186 DE-mRNA were found in the PD. Moreover, function annotation analysis indicated that the reproductive hormones and photoperiod response-related pathways including aldosterone synthesis and secretion, insulin secretion, thyroid hormone synthesis, and circadian entrainment were enriched. The interaction analysis of mRNA-lncRNA suggested that MSTRG.240648, MSTRG.85500, MSTRG.32448, and MSTRG.304959 targeted CREB3L1 and DUSP6, which may be involved in the photoperiodic regulation of the PD. These findings provide resources for further study on the seasonal reproductive in ewes.
Funder
National Natural Science Foundation of China
Tianjin Science and Technology Plan Project
Youth Innovative Research and Experimental Project of Tianjin Academy of Agricultural Sciences
Earmarked Fund for China Agriculture Research System
Agricultural Science and Technology Innovation Program of China
China Agricultural Scientific Research Outstanding Talents and Their Innovative Teams Program
China High-level Talents Special Support Plan Scientific and Technological Innovation Leading Talents Program
Joint Funds of the National Natural Science Foundation of China
Government of Xinjiang Uygur Autonomous Region of China
Subject
General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Cited by
11 articles.
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