Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth

Author:

Barsotti Anthony M.1,Ryskin Michael1,Zhong Wenyan1,Zhang Wei-Guo1,Giannakou Andreas1,Loreth Christine2,Diesl Veronica2,Follettie Maximillian12,Golas Jonathon1,Lee Michelle3,Nichols Timothy3,Fan Conglin4,Li Gang4,Dann Stephen4,Fantin Valeria R.4,Arndt Kim1,Verhelle Dominique4,Rollins Robert A.1

Affiliation:

1. Oncology Research Unit, Pfizer Worldwide Research and Development, Pearl River, NY 10965, USA

2. Oncology Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02140, USA

3. Drug Safety Research and Development, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA

4. Oncology Research Unit, Pfizer Worldwide Research and Development, San Diego, CA 92121, USA

Publisher

Impact Journals, LLC

Subject

Oncology

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