Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression-Reference-Cited by-同舟云学术

Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression

Published:2021-10-06 Issue:19 Volume:64 Page:14540-14556
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rej Rohan Kalyan,Wang Changwei,Lu Jianfeng,Wang Mi,Petrunak Elyse,Zawacki Kaitlin P.,McEachern Donna,Yang Chao-Yie¹^ORCID,Wang Lu,Li Ruiting,Chinnaswamy Krishnapriya,Wen Bo,Sun Duxin^ORCID,Stuckey Jeanne A.,Zhou Yunlong²,Chen Jianyong²,Tang Guozhi²,Wang Shaomeng^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States

2. Ascentage Pharma Group, Suzhou, Jiangsu 215216, China

Funder

National Cancer Institute

Ascentage Pharma Group

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01059