Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies

Author:

Breen Miyuki1,Nwanaji-Enwerem Jamaji C.234,Karrasch Stefan567,Flexeder Claudia6,Schulz Holger67,Waldenberger Melanie8,Kunze Sonja8,Ollert Markus910,Weidinger Stefan11,Colicino Elena12,Gao Xu13,Wang Cuicui2,Shen Jincheng14,Just Allan C.12,Vokonas Pantel15,Sparrow David15,Hou Lifang16,Schwartz Joel D.2,Baccarelli Andrea A.13,Peters Annette6,Ward-Caviness Cavin K.17

Affiliation:

1. Oak Ridge Institute for Science and Education (ORISE), Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC 27709, USA

2. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA

3. MD-PhD Program, Harvard Medical School, Boston, MA 02115, USA

4. Belfer Center for Science and International Affairs, Harvard Kennedy School of Government, Cambridge, MA 02138, USA

5. Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner Clinic, University Hospital of Munich, Ludwig-Maximilians-Universität, Munich, Germany

6. Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

7. Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Neuherberg, Germany

8. Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

9. Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg

10. Odense Research Center for Anaphylaxis, Department of Dermatology and Allergy Center, University of Southern Denmark, Odense, Denmark

11. Department of Genetic Dermatology, University of Kiel, Kiel, Germany

12. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

13. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA

14. Department of Population Health Sciences, University of Utah, School of Medicine, Salt Lake City, UT 84132, USA

15. Veterans Affairs Normative Aging Study, Veterans Affairs Boston Healthcare System, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA

16. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

17. Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC 27709, USA

Publisher

Impact Journals, LLC

Subject

Cell Biology,Aging

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