Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study-Reference-Cited by-同舟云学术

Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study

Published:2023-07 Issue:13 Volume:15 Page:693-703
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Joyce Brian T¹^ORCID,Chen Xuefen²,Gao Tao¹,Zheng Yinan¹,Nannini Drew R¹,Liu Lei³,Henkle Benjamin E⁴⁵,Kalhan Ravi¹,Washko George⁶,Kunisaki Ken M⁴⁵,Thyagarajan Bharat⁵,Vaughan Douglas E⁷,Gross Myron⁵,Jacobs David R⁵,Lloyd-Jones Donald¹,Hou Lifang¹⁷

Affiliation:

1. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

2. Department of Epidemiology of Health Statistics, School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, 201318, China

3. Division of Biostatistics, Washington University, St. Louis, MO 63110, USA

4. Minneapolis VA Health Care System, Minneapolis, MN 55417, USA

5. University of Minnesota, Minneapolis, MN 55455, USA

6. Harvard Medical School, Harvard University, Boston, MA 02115, USA

7. Potocsnak Longevity Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

Abstract

Background: The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. Methods: This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40–45 years), and prospective associations with emphysema at Y25 were examined. Results: At Y20, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0–Y10 cumulative measures, only the FEV1/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Conclusion: Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.

Funder

National Institute on Aging

National Heart, Lung, and Blood Institute

American Heart Association

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2023-0164

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